the TCF induction was higher than the induction in control cells

Curcumin has entered scientific clinical studies at clinical trial level and the phase I only within the last 10-15 years. A phase IItudy of jewel citabine, curcumin and celecoxib Gefitinib Iressa is because of open to recruit ment in the Tel AviSourasky Clinic for patients with metastatic colorectal cancer. Why curcumin Curcumin is a element of turmeric, the orange spice derived from the roots of the plant Curcuma longa. Curcuma longa is just a short stemmed perennial, which grows to about 100 cm tall. It has rounded leaves and square, ovate or cylindrical rhizomes. Curcuma longa grows naturally throughout the Indian sub-continent and in tropical countries, specially South East Asia. A normal treatment in Ayurvedic medicine and ancient Indian healing system that dates back over 5,000 years, turmeric has been used through the ages being an herbal cortisone and herbal aspirin Skin infection to relieve inflammation and vexation related to a rare spectrum of infectious and autoimmune diseases. Curcumin, diferuloylmethane chemically it is known, is the subject of a huge selection of bar lished papers over the past three years, studying its anti oxidant, anti hazardous, anti inflammatory, cancer chemopreventive and potentially chemotherapeutic prop erties. The pharmacology and putative anti-cancer houses of curcumin have been the subject of many review articles published since 1991, which pre date a number of clinical studies of curcumin which have been completed and published in the last couple of years. But these properties don't prove the superiority of this phytochemical over other chemotherapeutic agents that also induced apoptosis efficiently in cancer cells. Majority of chemotherapeutic agents, including these iso lated from plants not just cause cancer cell apoptosis but additionally severely damage the normal cells of the host, the effects being particularly severe in case there is the immune system. On the con trary, curcumin is a part of our everyday food behavior and its use within XL888 large quantities from ancient time has already proved that it is a safe product. In reality, since curcumin prefer ably induces apoptosis in extremely proliferating cells, death is much more pronounced in tumor cells than normal people. Report from our laboratory has shown that anticancer dose of curcumin arrests non-malignant cells in G0 phase reversibly but doesn't induce apoptosis included. Further studies unmasked that phytochemical protects T cells of the cancer bearer from cancer as well as chemotherapeutic agent induced apoptosis. The idea of this differential regulation might be related to its differential effects on normal and neoplastic cell cycles since deregulation of some aspects of cell cycle regu latory machinery could generate uncontrolled proliferation and thus neoplastic changes.