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Evaluating people who received lenalidomide plus dexamethasone Cilengitide as second line versus later salvage treatment, the ORR seemed higher with early treatment. A greater proportion of patients receiving second-line therapy had previously had SCT, while more patients receiving later salvage therapy had previously received thalidomide and bortezomib. In further subanalyses of MM 009 and MM 010, Foa and colleagues reported that among 154 patients with IgA disease at baseline, lenalidomide plus dexamethasone was associated with a dramatically higher ORR than dexamethasone alone. The CR rate in patients with IgA infection who have been addressed with lenalidomide plus dexamethasone, versus dexamethasone alone, was 18. 1% and 0%, respectively. Likewise, in patients without IgA illness at baseline, lenalidomide plus dexamethasone achieved an increased ORR weighed against dexamethasone alone. Another analysis demonstrated that the efficiency of lenalidomide plus dexamethasone compared with dexamethasone Eumycetoma alone was independent of baseline ECOG performance status. Within this analysis, people with an ECOG scores of 0 or 1 had somewhat higher ORR with lenalidomide plus dexamethasone compared with dexamethasone alone. Also, age didn't determine response to lenalidomide, with yet another subanalysis demonstrating that ORR was notably higher for lenalidomide plus dexamethasone compared with dexamethasone alone for patients aged 65 years, years, and 75 years. In a sub-group analysis of 682 individuals with serum creatinine levels of 2. 5 mg/dL at baseline, lenalidomide plus dexamethasone considerably increased response price compared with dexamethasone alone in patients with normal renal function and in those with mild and moderate renal impairment. The ORR was not notably different 2-ME2 between lenalidomide plus dexamethasone and dexamethasone alone within the 28 patients with significant renal impairment, with CR rates following a similar pattern to ORR. Finally, a post hoc analysis of information from the MM 009 and MM 010 trials indicated that dexamethasone dose reductions improved the efficacy of lenalidomide plus dexamethasone treatment compared with patients who continued to get dexamethasone in the planned dose. Patients assigned to lenalidomide plus dexamethasone and who had a future dexamethasone dose decline experienced a significantly higher ORR and CR price compared with patients who continued for the conventional dexamethasone regimen in combination with lenalidomide. Within an ongoing Dutch thoughtful need system, patients with relapsed or refractory MM were treated with lenalidomide 25 mg/day on days 21 every 28 days, in combination with dexamethasone 40 mg/day on days 18 until disease progression, unacceptable toxicity, or for a maximum of eight courses. Fifteen patients received lenalidomide 10 mg/day preservation therapy without dexamethasone after 8 courses of therapy.